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Feb 18, 2020

It has become quite evident that the microbiome has the potential to impact drug discovery in vital ways. In addition to impacting study reproducibility and variability, the microbiome may influence drug efficacy or serve as a therapeutic agent.

To capitalise on the microbiome’s potential to improve human health,...


Feb 4, 2020

Drug discovery is increasingly informed by genomics, which can significantly boost the chances of a novel therapy successfully navigating the lengthy journey from bench to bedside. But despite the rapid proliferation of genomic information, we still have a limited understanding of how specific genes and genetic...


Jan 21, 2020

Flow cytometry is an invaluable technique for the characterisation of highly heterogeneous cell populations.

Thanks to improvements in throughput, automation and multichannel detection capabilities, recent years have seen its use expand across a wide range of drug discovery applications.

In this article, we look at...


Jan 7, 2020

Despite major investment in the field, few cell therapies have gained regulatory approval with limited commercial success.

The success of therapeutic products is defined by three factors: safety, efficacy and scalability. Achieving these for cell therapy presents new challenges; overcoming transplant rejection (and...


Dec 10, 2019

Drug discovery teams combine specialists with in-depth knowledge from a variety of scientific disciplines. Such diversity in thought worlds poses a challenging exercise in cross-disciplinary collaboration and project coordination.

Based on a longitudinal field study of five projects in a leading pharmaceutical company,...