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Oct 9, 2018

RNA-seq has revolutionised how scientists can interrogate gene expression. But after years of performing RNA-seq studies with short-read sequencers, many have realised that there is more to be discovered.

Comprehensive transcriptome analysis – an essential tool for characterising disease, studying cell lines and measuring drug response – requires a more thorough approach.

New studies have demonstrated that longread sequencing, which spans full-length isoforms without the need to reassemble fragmented data, can detect novel genes, transcripts and gene fusions even in well-characterised samples.

Long-read sequencing has provided an indepth view of alternative splicing, revealing far more of this mechanism than has previously been observed. It also enables detection of critical elements such as long, non-coding RNAs.

Original article by Luke Hickey

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