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Jan 30, 2018

Derisking is the intelligent application of early in vitro testing to investigate areas of major risk for a new molecule in development, helping to avoid spending time and resource on a compound that may carry with it a high potential liability of nonapproval or market withdrawal. Derisking provides information that...


Jan 24, 2018

In this episode, we explore different novel business models to solve this problem of developing new drugs, we discuss The Harrington Project, Milner Therapeutics Institute, the Tri-Institutional Therapeutics Discovery Institute, as examples of strategic arrangements, before finally concluding.

The original article this...


Jan 16, 2018

In this episode, we explore how artificial intelligence (AI) can transform the scientific method and, in turn, the pharmaceutical industry. We discuss the barriers to drug development, AI’s role, and finally how embracing technology can revolutionise the drug discovery process.

The original article this episode is...


Jan 12, 2018

In this episode (part 2), we begin by discussing where we are now, we then talk about rational design and iterative discovery in a modern world, the model: nuclei or electrons, testing and effective use of time and technologies, the future, before finally presenting our strategic vision for 21st century...


Jan 12, 2018

In this episode (part 1), we give a brief history of drug discovery, discuss the 1980’s and the shift in approach, the effects of the new approach, recent approaches to improve return, chemistry, and fragment based lead discovery.

The original article this episode is based on was written by Dr Wayne Bowen, Dr Giles...