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Sep 25, 2018

Technologies have been honed to overcome many of the challenges of administering peptide therapeutics orally, but obstacles remain before drug developers can fully realise the vast potential.

Proteins and peptides are the building blocks of life and have evolved to become a very promising basis for targeting a range...


Sep 18, 2018

CRISPR-Cas9 has rapidly transformed our ability to perform targeted gene editing. While the technique has received much interest for its potential in the field of gene therapy, advances in its high-throughput use mean it can now open up a wealth of opportunities in drug discovery too.

CRISPR-Cas9, short for clustered...


Sep 11, 2018

A silo mentality is an issue for any organisation, but it is particularly problematic for the pharmaceutical industry. Drug development is a multidisciplinary endeavour that relies on the cumulative efforts of highly skilled teams in order to be successful. Yet these teams cannot work in isolation.

Few development...


Sep 4, 2018

The first results for the Reproducibility Project: Cancer Biology offer insights into the time and cost of conducting replication studies in preclinical cancer biology.

While many agree that developing a therapeutic should not be pursued unless grounded in reproducible preclinical results, the costs of replication have,...