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Jun 23, 2020

Live-cell imaging has transformed the study of cell behaviour and function. The technique allows researchers to monitor internal cell structures, interactions and processes in real-time, and over time.

In drug discovery, understanding the dynamic processes of cells provides an enhanced picture of drug pharmacology,...


Jun 9, 2020

New disease targets frequently emerge in literature, but the thorough target validation required to consider these targets for a drug discovery programme is often lacking.

In pharmacological or genetic perturbation studies using complex biological assays, undesired off-target effects cannot be easily distinguished from...


May 26, 2020

This article discusses opportunities, challenges and best practices in leveraging infrastructure excellence and AI to unlock the value of early or inconclusive clinical trial data. The goal... driving stronger biomarker-based insights and decisions and helping to advance new cures and treatment approaches.

As we all...


May 12, 2020

The publication of the first human genome sequence more than 15 years ago marked the start of a new era in medicine. In the years since then, researchers have greatly expanded knowledge of gene-disease links and gained a better understanding of the underlying molecular pathways.

The first precision therapies, targeted...


Apr 28, 2020

In light of the high failure rate of compounds when they are subjected to clinical testing, we are seeing a renaissance in phenotypic screening in drug discovery. However, most phenotypic screening is based on the use of cellular assays and here we debate the advantages and disadvantages of single-cell versus...