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Jan 15, 2019

Commercially available high-content imaging (HCI) systems, introduced in the 1990s, have provided the scientific community with a platform that offers a unique set of tools ideal for advancing high-throughput biological discoveries and therapeutic development.

High-content imaging has made it possible to interrogate specific biological responses on heterotypic populations of cells, sub-populations of cells within a large population, and even within individual single cells. Today, this technology is becoming widespread across many scientific disciplines and has been used in nearly all capacities of biological and biochemical research studies.

The plethora of experimental assays and cell models designed and used to produce HCI data from these sophisticated imaging systems has now grown from simple two-dimensional (2D) monolayer cell culture models to more complex three-dimensional (3D) organotypic cell models or organoids and whole organisms (examples include, Zebrafish and C. elegans) to determine biological outcomes including measuring the phenotypic characteristics in context of the tissue.

Original article by O. Joseph Trask, Dr Daniel V. LaBarbera and Dr Kevin Quick

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