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Aug 31, 2018

Optimizing the receptor binding kinetics of new drugs can have significant benefits, ranging from improved duration of action to enhanced efficacy through the insurmountable antagonism of dynamic physiological systems. Despite this, the kinetics of new receptor ligands are rarely measured early in the drug discovery...


Aug 28, 2018

The human kinome comprises 518 known protein kinases and more than 20 lipid kinases. Nearly all aspects of control within a cell are modulated by reversible phosphorylation of proteins, mediated by protein kinases.

Abnormal phosphorylation is a cause or effect of many diseases including cancer and inflammatory diseases,...


Aug 21, 2018

Smac mimetics are a new class of targeted drugs being developed for the treatment of solid tumours and hematologic cancers. Smac mimetics specifically induce apoptotic cancer cell death and block pro-survival signalling in cancer cells.

This episode provides an overview of the biology of Smac, an endogenous...


Aug 14, 2018

This episode summarises some of the technical and regulatory challenges posed by next-generation sequencing technologies and the efforts being made to address them.

Next-Generation Sequencing is moving quickly from early research into the regulated domains of drug development, diagnostic development, and clinical...


Aug 7, 2018

This episode discusses issues around artificial intelligence & Biopharma R&D IT, and outlines how AI can be a potentially transformative technology for the biopharmaceutical and healthcare industries.

"...R&D productivity remains an ongoing concern. Artificial Intelligence and the accompanying analytics are now so...