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Feb 27, 2018

Epigenetic factors are rapidly taking the spotlight as major players in the critical pathways that trigger the onset and progression of numerous life-threatening and debilitating genetic diseases. Technologies that harness our growing knowledge of epigenetic mechanisms look set to revolutionise approaches to medicine...


Feb 21, 2018

Nanoparticles, and liposomes in particular, are growing in popularity as drug delivery vehicles for anti-cancer agents and inflammatory disease therapies, as well as forming the basis of a new class of vaccines. In this episode we explore nanomedicines past, present and future and their role in drug discovery and...


Feb 16, 2018

In this episode, part 2 that is continued from the previous episode, we discuss: Process chemistry/route selection; Drug metabolism: the case of cytochrome; Metalloporphyrins as chemical mimics of cytochrome P-450 systems; Diversified analogues through automated oxidation chemistry; Precision Medicine; Precision...


Feb 13, 2018

In this episode we discuss: current drug approvals; translational chemical biology – the knowledge deficit; reverse pharmacology observational therapeutics; renaissance of plant-based natural products; expanding chemical space; hybrid molecules; flow chemistry and chemoinformatics.

The original article this episode is...


Feb 6, 2018

Cancer is still one of the main causes of death worldwide, yet recent strides towards more effective treatments have been made in the form of new cancer immunotherapies. By weaponising the body’s own immune defences, these drugs have shown great promise in clinical trials and are now experiencing significant...