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Dec 18, 2018

Mass spectrometry (MS) has long been a valuable tool for drug discovery, and steady advances in its capabilities and performance have generated powerful insights for the pharmaceutical industry. The latest MS innovations are now helping biotherapeutics developers overcome challenges around sample preparation and large molecule analysis.

The use of mass spectrometry in pharmaceutical discovery and development is rich and varied, spanning a wealth of applications from target discovery, medicinal chemistry, pharmacokinetics and bioanalysis workflows, to name just a few.

Offering the selectivity, specificity and sensitivity required to answer a broad range of analytical questions, mass spectrometry has become one of the most powerful tools in the drug discovery toolbox.

Mass spectrometry is a particularly powerful tool for the discovery and development of biotherapeutics. Today, biotherapeutic products account for a growing proportion of new drug approvals. Increased focus on the development of much larger, more complex therapeutics such as monoclonal antibodies, fusion proteins and antibody-drug conjugates has placed new demands on mass spectrometry.

Original article by Helen Stewart-Miller and Dr Richard Massey

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